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Bacterial cell

Microbiology · Prokaryotic cell

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How does a living thing hundreds of times smaller than a grain of sand swim, sense food and copy itself?

A bacterium like E. coli is a single tiny cell, about 2 micrometres long, with no nucleus inside. It is wrapped in layers of skin and a tough wall, keeps its DNA in a loose tangle in the middle, and swims by spinning long corkscrew-shaped tails with tiny rotary motors. Every 20 minutes or so, in good conditions, it can split into two.

Bacteria are prokaryotes: their DNA lies in a nucleoid in the cytoplasm, with no nucleus or membrane-bound organelles, and the plasma membrane does the work that mitochondria do in eukaryotes. A Gram-negative rod such as Escherichia coli is wrapped in a layered envelope — inner membrane, thin peptidoglycan wall and outer membrane — and swims by rotating helical flagella with ion-driven motors.

Key facts

Size (E. coli)
≈ 1–2 µm long, 0.8–1 µm wide; volume ≈ 1 fL
Chromosome
≈ 4.6 Mb circular DNA, ≈ 4,300 protein-coding genes
Ribosomes per cell
≈ 10,000–70,000, rising with growth rate
Doubling time
≈ 20 min in rich medium at 37 °C
Flagella
≈ 4–8 per cell; filaments ≈ 20 nm thick, 5–10 µm long
Swimming speed
≈ 20–30 µm/s (≈ 10–15 body lengths per second)

Parts you can explore (13)

In the 3D model

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